Endophenotypes in psychiatric genetics
نویسندگان
چکیده
منابع مشابه
Bringing genetics back to psychiatric endophenotypes.
t T he concept of endophenotypes, introduced almost 4 decades ago, has become increasingly important in the study of complex neuropsychiatric diseases. Endophenotypes are easurable, but not overtly observable, constructs in the pathway rom genetic variation to psychiatric disorder. As originally concepualized, endophenotypes must: 1) be associated with illness in the opulation; 2) be heritable;...
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This article reviews the concept of an endophenotype, with particular reference to heritability as well as diagnostic specificity. An endophenotype need not be heritable, for example, the possible influence of in utero viral infections for schizophrenia. However, heritability is a useful characteristic for a potential endophenotype, as it can be studied in relation to a plausible candidate gene...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2007
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4002068